Ubiquitin Proteomics:Article Title: Targeting the cGAS-STING Pathway: An Emerging Therapeutic Strategy for Digestive Diseases.
Article Snippet: Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology Copyright ©2026 The Author(s). .. Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology Liver HBV interacting with STING and inhibiting ubiquitination at its K63 site HepaRG cells primary human hepatocytes HBV replication was significantly inhibited when the cGAS-STING pathway was activated by either dsDNA or cGAMP cancer patients, mice STING activated [40] NAFLD STING levels in non-solid cells of liver tissue were higher in NAFLD patients than in non-NAFLD patients. mice with disruption of Tmem173 STING activated [115] NASH STING deficiency attenuates hepatic steatosis, fibrosis and inflammation in two NASH mouse models NASH in mice STING inhibited [48] ALD Disruption of Cx32 impairs IRF3 gene expression ALD patient Cx32KO mice STING inhibited [51] IRI Knockdown of STING in macrophages significantly attenuates aging-related deterioration of hepatic IRIs C57/BL6 mice STING inhibited [54] Liver fibrosis XBP1 regulates macrophage mtDNA cytoplasmic leakage via BNIP3-mediated regulation of mitochondrial autophagy to activate macrophage cGAS/STING/NLRP3 and exacerbate liver fibrosis mice and patients with Xbp1 knockout XBP1/STING/NLRP3 activated [62] Fluoropropylene oxide trimeric acid (HFPO-TA) mediates cellular cGAS/STING/NLRP3 activation through mitochondrial ROS (mtROS) overexpression and accelerates liver fibrosis progression C57/BL6 mice STING/NLRP3 activated [63] Hepatocellular Carcinoma TET2-mediated IL-2/STAT5A signaling upregulates cGAS expression in hepatocellular carcinoma tumors and produces cGAMP. cGAMP is Hepa1-6 Huh7 TET2/IL-2/STAT5A/ STING activated [66] Copyright ©2026 The Author(s). .. Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology transported through LRRC8C channels to activate STING in endothelial cells Pancreatic Acute pancreatitis STING is activated by sensing PAC death and promotes inflammatory cytokine and IFN production, exacerbating AP severity C57BL/6J mice C57BL/6J-Tmem 173gt/J mice TMEM 173/STING activated [74] Knockdown of wip 1 inhibits the STING-TBK 1 signaling pathway, suppresses AP autophagy, and reduces AP severity 28-week-old male SD rats Wip1/STING inhibited [77] Inhibition of the pro-inflammatory factor enhancer JMJD3 blocked mtDNA oxidation and knocked down the TLR 9/STING pathway effectively reduced inflammation C57BL/6 mice(M) JMJD3/TLR9/STING inhibited [75] SSd protects PAC from rainfroggin-induced pyroptosis by attenuating mitochondrial damage and inhibiting the cGAS-STING signaling pathway, attenuating AP AR42J cell line SSd/STING inhibited [76] Chronic Pancreatitis DMXAA activates STING signaling and limits Th 17 response in the pancreas, significantly relieving CP symptoms C57BL/6J mice, C57BL/6J-Tmem 173gt/J mice DMXAA/STING activated [79] Pancreatic cancer Inhibition of DTX 3L leads to enhanced activation of cGAS-STING signaling pathway and improves anti-tumor immunity in pancreatic cancer C57BL/6J mice(F) DTX3L/STING activated [88] Colorectal Ulcerative colitis PAD4-mediated NETs activate the cGAS-STING pathway in a dose- and time-dependent manner, leading to the secretion of inflammatory cytokines and impaired barrier function C57BL/6 mice PAD4/NETs/STING activated [101] ANP repairs the intestinal barrier and inhibits ER stress-induced autophagy by inhibiting STING 8week-old C57BL/6 mice(M) ANP/STING inhibited [94] Copyright ©2026 The Author(s).
Disruption:Article Title: Targeting the cGAS-STING Pathway: An Emerging Therapeutic Strategy for Digestive Diseases.
Article Snippet: Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology Copyright ©2026 The Author(s). .. Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology Liver HBV interacting with STING and inhibiting ubiquitination at its K63 site HepaRG cells primary human hepatocytes HBV replication was significantly inhibited when the cGAS-STING pathway was activated by either dsDNA or cGAMP cancer patients, mice STING activated [40] NAFLD STING levels in non-solid cells of liver tissue were higher in NAFLD patients than in non-NAFLD patients. mice with disruption of Tmem173 STING activated [115] NASH STING deficiency attenuates hepatic steatosis, fibrosis and inflammation in two NASH mouse models NASH in mice STING inhibited [48] ALD Disruption of Cx32 impairs IRF3 gene expression ALD patient Cx32KO mice STING inhibited [51] IRI Knockdown of STING in macrophages significantly attenuates aging-related deterioration of hepatic IRIs C57/BL6 mice STING inhibited [54] Liver fibrosis XBP1 regulates macrophage mtDNA cytoplasmic leakage via BNIP3-mediated regulation of mitochondrial autophagy to activate macrophage cGAS/STING/NLRP3 and exacerbate liver fibrosis mice and patients with Xbp1 knockout XBP1/STING/NLRP3 activated [62] Fluoropropylene oxide trimeric acid (HFPO-TA) mediates cellular cGAS/STING/NLRP3 activation through mitochondrial ROS (mtROS) overexpression and accelerates liver fibrosis progression C57/BL6 mice STING/NLRP3 activated [63] Hepatocellular Carcinoma TET2-mediated IL-2/STAT5A signaling upregulates cGAS expression in hepatocellular carcinoma tumors and produces cGAMP. cGAMP is Hepa1-6 Huh7 TET2/IL-2/STAT5A/ STING activated [66] Copyright ©2026 The Author(s). .. Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology transported through LRRC8C channels to activate STING in endothelial cells Pancreatic Acute pancreatitis STING is activated by sensing PAC death and promotes inflammatory cytokine and IFN production, exacerbating AP severity C57BL/6J mice C57BL/6J-Tmem 173gt/J mice TMEM 173/STING activated [74] Knockdown of wip 1 inhibits the STING-TBK 1 signaling pathway, suppresses AP autophagy, and reduces AP severity 28-week-old male SD rats Wip1/STING inhibited [77] Inhibition of the pro-inflammatory factor enhancer JMJD3 blocked mtDNA oxidation and knocked down the TLR 9/STING pathway effectively reduced inflammation C57BL/6 mice(M) JMJD3/TLR9/STING inhibited [75] SSd protects PAC from rainfroggin-induced pyroptosis by attenuating mitochondrial damage and inhibiting the cGAS-STING signaling pathway, attenuating AP AR42J cell line SSd/STING inhibited [76] Chronic Pancreatitis DMXAA activates STING signaling and limits Th 17 response in the pancreas, significantly relieving CP symptoms C57BL/6J mice, C57BL/6J-Tmem 173gt/J mice DMXAA/STING activated [79] Pancreatic cancer Inhibition of DTX 3L leads to enhanced activation of cGAS-STING signaling pathway and improves anti-tumor immunity in pancreatic cancer C57BL/6J mice(F) DTX3L/STING activated [88] Colorectal Ulcerative colitis PAD4-mediated NETs activate the cGAS-STING pathway in a dose- and time-dependent manner, leading to the secretion of inflammatory cytokines and impaired barrier function C57BL/6 mice PAD4/NETs/STING activated [101] ANP repairs the intestinal barrier and inhibits ER stress-induced autophagy by inhibiting STING 8week-old C57BL/6 mice(M) ANP/STING inhibited [94] Copyright ©2026 The Author(s).
Gene Expression:Article Title: Targeting the cGAS-STING Pathway: An Emerging Therapeutic Strategy for Digestive Diseases.
Article Snippet: Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology Copyright ©2026 The Author(s). .. Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology Liver HBV interacting with STING and inhibiting ubiquitination at its K63 site HepaRG cells primary human hepatocytes HBV replication was significantly inhibited when the cGAS-STING pathway was activated by either dsDNA or cGAMP cancer patients, mice STING activated [40] NAFLD STING levels in non-solid cells of liver tissue were higher in NAFLD patients than in non-NAFLD patients. mice with disruption of Tmem173 STING activated [115] NASH STING deficiency attenuates hepatic steatosis, fibrosis and inflammation in two NASH mouse models NASH in mice STING inhibited [48] ALD Disruption of Cx32 impairs IRF3 gene expression ALD patient Cx32KO mice STING inhibited [51] IRI Knockdown of STING in macrophages significantly attenuates aging-related deterioration of hepatic IRIs C57/BL6 mice STING inhibited [54] Liver fibrosis XBP1 regulates macrophage mtDNA cytoplasmic leakage via BNIP3-mediated regulation of mitochondrial autophagy to activate macrophage cGAS/STING/NLRP3 and exacerbate liver fibrosis mice and patients with Xbp1 knockout XBP1/STING/NLRP3 activated [62] Fluoropropylene oxide trimeric acid (HFPO-TA) mediates cellular cGAS/STING/NLRP3 activation through mitochondrial ROS (mtROS) overexpression and accelerates liver fibrosis progression C57/BL6 mice STING/NLRP3 activated [63] Hepatocellular Carcinoma TET2-mediated IL-2/STAT5A signaling upregulates cGAS expression in hepatocellular carcinoma tumors and produces cGAMP. cGAMP is Hepa1-6 Huh7 TET2/IL-2/STAT5A/ STING activated [66] Copyright ©2026 The Author(s). .. Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology transported through LRRC8C channels to activate STING in endothelial cells Pancreatic Acute pancreatitis STING is activated by sensing PAC death and promotes inflammatory cytokine and IFN production, exacerbating AP severity C57BL/6J mice C57BL/6J-Tmem 173gt/J mice TMEM 173/STING activated [74] Knockdown of wip 1 inhibits the STING-TBK 1 signaling pathway, suppresses AP autophagy, and reduces AP severity 28-week-old male SD rats Wip1/STING inhibited [77] Inhibition of the pro-inflammatory factor enhancer JMJD3 blocked mtDNA oxidation and knocked down the TLR 9/STING pathway effectively reduced inflammation C57BL/6 mice(M) JMJD3/TLR9/STING inhibited [75] SSd protects PAC from rainfroggin-induced pyroptosis by attenuating mitochondrial damage and inhibiting the cGAS-STING signaling pathway, attenuating AP AR42J cell line SSd/STING inhibited [76] Chronic Pancreatitis DMXAA activates STING signaling and limits Th 17 response in the pancreas, significantly relieving CP symptoms C57BL/6J mice, C57BL/6J-Tmem 173gt/J mice DMXAA/STING activated [79] Pancreatic cancer Inhibition of DTX 3L leads to enhanced activation of cGAS-STING signaling pathway and improves anti-tumor immunity in pancreatic cancer C57BL/6J mice(F) DTX3L/STING activated [88] Colorectal Ulcerative colitis PAD4-mediated NETs activate the cGAS-STING pathway in a dose- and time-dependent manner, leading to the secretion of inflammatory cytokines and impaired barrier function C57BL/6 mice PAD4/NETs/STING activated [101] ANP repairs the intestinal barrier and inhibits ER stress-induced autophagy by inhibiting STING 8week-old C57BL/6 mice(M) ANP/STING inhibited [94] Copyright ©2026 The Author(s).
Knockdown:Article Title: Targeting the cGAS-STING Pathway: An Emerging Therapeutic Strategy for Digestive Diseases.
Article Snippet: Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology Copyright ©2026 The Author(s). .. Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology Liver HBV interacting with STING and inhibiting ubiquitination at its K63 site HepaRG cells primary human hepatocytes HBV replication was significantly inhibited when the cGAS-STING pathway was activated by either dsDNA or cGAMP cancer patients, mice STING activated [40] NAFLD STING levels in non-solid cells of liver tissue were higher in NAFLD patients than in non-NAFLD patients. mice with disruption of Tmem173 STING activated [115] NASH STING deficiency attenuates hepatic steatosis, fibrosis and inflammation in two NASH mouse models NASH in mice STING inhibited [48] ALD Disruption of Cx32 impairs IRF3 gene expression ALD patient Cx32KO mice STING inhibited [51] IRI Knockdown of STING in macrophages significantly attenuates aging-related deterioration of hepatic IRIs C57/BL6 mice STING inhibited [54] Liver fibrosis XBP1 regulates macrophage mtDNA cytoplasmic leakage via BNIP3-mediated regulation of mitochondrial autophagy to activate macrophage cGAS/STING/NLRP3 and exacerbate liver fibrosis mice and patients with Xbp1 knockout XBP1/STING/NLRP3 activated [62] Fluoropropylene oxide trimeric acid (HFPO-TA) mediates cellular cGAS/STING/NLRP3 activation through mitochondrial ROS (mtROS) overexpression and accelerates liver fibrosis progression C57/BL6 mice STING/NLRP3 activated [63] Hepatocellular Carcinoma TET2-mediated IL-2/STAT5A signaling upregulates cGAS expression in hepatocellular carcinoma tumors and produces cGAMP. cGAMP is Hepa1-6 Huh7 TET2/IL-2/STAT5A/ STING activated [66] Copyright ©2026 The Author(s). .. Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology transported through LRRC8C channels to activate STING in endothelial cells Pancreatic Acute pancreatitis STING is activated by sensing PAC death and promotes inflammatory cytokine and IFN production, exacerbating AP severity C57BL/6J mice C57BL/6J-Tmem 173gt/J mice TMEM 173/STING activated [74] Knockdown of wip 1 inhibits the STING-TBK 1 signaling pathway, suppresses AP autophagy, and reduces AP severity 28-week-old male SD rats Wip1/STING inhibited [77] Inhibition of the pro-inflammatory factor enhancer JMJD3 blocked mtDNA oxidation and knocked down the TLR 9/STING pathway effectively reduced inflammation C57BL/6 mice(M) JMJD3/TLR9/STING inhibited [75] SSd protects PAC from rainfroggin-induced pyroptosis by attenuating mitochondrial damage and inhibiting the cGAS-STING signaling pathway, attenuating AP AR42J cell line SSd/STING inhibited [76] Chronic Pancreatitis DMXAA activates STING signaling and limits Th 17 response in the pancreas, significantly relieving CP symptoms C57BL/6J mice, C57BL/6J-Tmem 173gt/J mice DMXAA/STING activated [79] Pancreatic cancer Inhibition of DTX 3L leads to enhanced activation of cGAS-STING signaling pathway and improves anti-tumor immunity in pancreatic cancer C57BL/6J mice(F) DTX3L/STING activated [88] Colorectal Ulcerative colitis PAD4-mediated NETs activate the cGAS-STING pathway in a dose- and time-dependent manner, leading to the secretion of inflammatory cytokines and impaired barrier function C57BL/6 mice PAD4/NETs/STING activated [101] ANP repairs the intestinal barrier and inhibits ER stress-induced autophagy by inhibiting STING 8week-old C57BL/6 mice(M) ANP/STING inhibited [94] Copyright ©2026 The Author(s).
Knock-Out:Article Title: Targeting the cGAS-STING Pathway: An Emerging Therapeutic Strategy for Digestive Diseases.
Article Snippet: Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology Copyright ©2026 The Author(s). .. Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology Liver HBV interacting with STING and inhibiting ubiquitination at its K63 site HepaRG cells primary human hepatocytes HBV replication was significantly inhibited when the cGAS-STING pathway was activated by either dsDNA or cGAMP cancer patients, mice STING activated [40] NAFLD STING levels in non-solid cells of liver tissue were higher in NAFLD patients than in non-NAFLD patients. mice with disruption of Tmem173 STING activated [115] NASH STING deficiency attenuates hepatic steatosis, fibrosis and inflammation in two NASH mouse models NASH in mice STING inhibited [48] ALD Disruption of Cx32 impairs IRF3 gene expression ALD patient Cx32KO mice STING inhibited [51] IRI Knockdown of STING in macrophages significantly attenuates aging-related deterioration of hepatic IRIs C57/BL6 mice STING inhibited [54] Liver fibrosis XBP1 regulates macrophage mtDNA cytoplasmic leakage via BNIP3-mediated regulation of mitochondrial autophagy to activate macrophage cGAS/STING/NLRP3 and exacerbate liver fibrosis mice and patients with Xbp1 knockout XBP1/STING/NLRP3 activated [62] Fluoropropylene oxide trimeric acid (HFPO-TA) mediates cellular cGAS/STING/NLRP3 activation through mitochondrial ROS (mtROS) overexpression and accelerates liver fibrosis progression C57/BL6 mice STING/NLRP3 activated [63] Hepatocellular Carcinoma TET2-mediated IL-2/STAT5A signaling upregulates cGAS expression in hepatocellular carcinoma tumors and produces cGAMP. cGAMP is Hepa1-6 Huh7 TET2/IL-2/STAT5A/ STING activated [66] Copyright ©2026 The Author(s). .. Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology transported through LRRC8C channels to activate STING in endothelial cells Pancreatic Acute pancreatitis STING is activated by sensing PAC death and promotes inflammatory cytokine and IFN production, exacerbating AP severity C57BL/6J mice C57BL/6J-Tmem 173gt/J mice TMEM 173/STING activated [74] Knockdown of wip 1 inhibits the STING-TBK 1 signaling pathway, suppresses AP autophagy, and reduces AP severity 28-week-old male SD rats Wip1/STING inhibited [77] Inhibition of the pro-inflammatory factor enhancer JMJD3 blocked mtDNA oxidation and knocked down the TLR 9/STING pathway effectively reduced inflammation C57BL/6 mice(M) JMJD3/TLR9/STING inhibited [75] SSd protects PAC from rainfroggin-induced pyroptosis by attenuating mitochondrial damage and inhibiting the cGAS-STING signaling pathway, attenuating AP AR42J cell line SSd/STING inhibited [76] Chronic Pancreatitis DMXAA activates STING signaling and limits Th 17 response in the pancreas, significantly relieving CP symptoms C57BL/6J mice, C57BL/6J-Tmem 173gt/J mice DMXAA/STING activated [79] Pancreatic cancer Inhibition of DTX 3L leads to enhanced activation of cGAS-STING signaling pathway and improves anti-tumor immunity in pancreatic cancer C57BL/6J mice(F) DTX3L/STING activated [88] Colorectal Ulcerative colitis PAD4-mediated NETs activate the cGAS-STING pathway in a dose- and time-dependent manner, leading to the secretion of inflammatory cytokines and impaired barrier function C57BL/6 mice PAD4/NETs/STING activated [101] ANP repairs the intestinal barrier and inhibits ER stress-induced autophagy by inhibiting STING 8week-old C57BL/6 mice(M) ANP/STING inhibited [94] Copyright ©2026 The Author(s).
Activation Assay:Article Title: Targeting the cGAS-STING Pathway: An Emerging Therapeutic Strategy for Digestive Diseases.
Article Snippet: Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology Copyright ©2026 The Author(s). .. Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology Liver HBV interacting with STING and inhibiting ubiquitination at its K63 site HepaRG cells primary human hepatocytes HBV replication was significantly inhibited when the cGAS-STING pathway was activated by either dsDNA or cGAMP cancer patients, mice STING activated [40] NAFLD STING levels in non-solid cells of liver tissue were higher in NAFLD patients than in non-NAFLD patients. mice with disruption of Tmem173 STING activated [115] NASH STING deficiency attenuates hepatic steatosis, fibrosis and inflammation in two NASH mouse models NASH in mice STING inhibited [48] ALD Disruption of Cx32 impairs IRF3 gene expression ALD patient Cx32KO mice STING inhibited [51] IRI Knockdown of STING in macrophages significantly attenuates aging-related deterioration of hepatic IRIs C57/BL6 mice STING inhibited [54] Liver fibrosis XBP1 regulates macrophage mtDNA cytoplasmic leakage via BNIP3-mediated regulation of mitochondrial autophagy to activate macrophage cGAS/STING/NLRP3 and exacerbate liver fibrosis mice and patients with Xbp1 knockout XBP1/STING/NLRP3 activated [62] Fluoropropylene oxide trimeric acid (HFPO-TA) mediates cellular cGAS/STING/NLRP3 activation through mitochondrial ROS (mtROS) overexpression and accelerates liver fibrosis progression C57/BL6 mice STING/NLRP3 activated [63] Hepatocellular Carcinoma TET2-mediated IL-2/STAT5A signaling upregulates cGAS expression in hepatocellular carcinoma tumors and produces cGAMP. cGAMP is Hepa1-6 Huh7 TET2/IL-2/STAT5A/ STING activated [66] Copyright ©2026 The Author(s). .. Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology transported through LRRC8C channels to activate STING in endothelial cells Pancreatic Acute pancreatitis STING is activated by sensing PAC death and promotes inflammatory cytokine and IFN production, exacerbating AP severity C57BL/6J mice C57BL/6J-Tmem 173gt/J mice TMEM 173/STING activated [74] Knockdown of wip 1 inhibits the STING-TBK 1 signaling pathway, suppresses AP autophagy, and reduces AP severity 28-week-old male SD rats Wip1/STING inhibited [77] Inhibition of the pro-inflammatory factor enhancer JMJD3 blocked mtDNA oxidation and knocked down the TLR 9/STING pathway effectively reduced inflammation C57BL/6 mice(M) JMJD3/TLR9/STING inhibited [75] SSd protects PAC from rainfroggin-induced pyroptosis by attenuating mitochondrial damage and inhibiting the cGAS-STING signaling pathway, attenuating AP AR42J cell line SSd/STING inhibited [76] Chronic Pancreatitis DMXAA activates STING signaling and limits Th 17 response in the pancreas, significantly relieving CP symptoms C57BL/6J mice, C57BL/6J-Tmem 173gt/J mice DMXAA/STING activated [79] Pancreatic cancer Inhibition of DTX 3L leads to enhanced activation of cGAS-STING signaling pathway and improves anti-tumor immunity in pancreatic cancer C57BL/6J mice(F) DTX3L/STING activated [88] Colorectal Ulcerative colitis PAD4-mediated NETs activate the cGAS-STING pathway in a dose- and time-dependent manner, leading to the secretion of inflammatory cytokines and impaired barrier function C57BL/6 mice PAD4/NETs/STING activated [101] ANP repairs the intestinal barrier and inhibits ER stress-induced autophagy by inhibiting STING 8week-old C57BL/6 mice(M) ANP/STING inhibited [94] Copyright ©2026 The Author(s).
Over Expression:Article Title: Targeting the cGAS-STING Pathway: An Emerging Therapeutic Strategy for Digestive Diseases.
Article Snippet: Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology Copyright ©2026 The Author(s). .. Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology Liver HBV interacting with STING and inhibiting ubiquitination at its K63 site HepaRG cells primary human hepatocytes HBV replication was significantly inhibited when the cGAS-STING pathway was activated by either dsDNA or cGAMP cancer patients, mice STING activated [40] NAFLD STING levels in non-solid cells of liver tissue were higher in NAFLD patients than in non-NAFLD patients. mice with disruption of Tmem173 STING activated [115] NASH STING deficiency attenuates hepatic steatosis, fibrosis and inflammation in two NASH mouse models NASH in mice STING inhibited [48] ALD Disruption of Cx32 impairs IRF3 gene expression ALD patient Cx32KO mice STING inhibited [51] IRI Knockdown of STING in macrophages significantly attenuates aging-related deterioration of hepatic IRIs C57/BL6 mice STING inhibited [54] Liver fibrosis XBP1 regulates macrophage mtDNA cytoplasmic leakage via BNIP3-mediated regulation of mitochondrial autophagy to activate macrophage cGAS/STING/NLRP3 and exacerbate liver fibrosis mice and patients with Xbp1 knockout XBP1/STING/NLRP3 activated [62] Fluoropropylene oxide trimeric acid (HFPO-TA) mediates cellular cGAS/STING/NLRP3 activation through mitochondrial ROS (mtROS) overexpression and accelerates liver fibrosis progression C57/BL6 mice STING/NLRP3 activated [63] Hepatocellular Carcinoma TET2-mediated IL-2/STAT5A signaling upregulates cGAS expression in hepatocellular carcinoma tumors and produces cGAMP. cGAMP is Hepa1-6 Huh7 TET2/IL-2/STAT5A/ STING activated [66] Copyright ©2026 The Author(s). .. Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology transported through LRRC8C channels to activate STING in endothelial cells Pancreatic Acute pancreatitis STING is activated by sensing PAC death and promotes inflammatory cytokine and IFN production, exacerbating AP severity C57BL/6J mice C57BL/6J-Tmem 173gt/J mice TMEM 173/STING activated [74] Knockdown of wip 1 inhibits the STING-TBK 1 signaling pathway, suppresses AP autophagy, and reduces AP severity 28-week-old male SD rats Wip1/STING inhibited [77] Inhibition of the pro-inflammatory factor enhancer JMJD3 blocked mtDNA oxidation and knocked down the TLR 9/STING pathway effectively reduced inflammation C57BL/6 mice(M) JMJD3/TLR9/STING inhibited [75] SSd protects PAC from rainfroggin-induced pyroptosis by attenuating mitochondrial damage and inhibiting the cGAS-STING signaling pathway, attenuating AP AR42J cell line SSd/STING inhibited [76] Chronic Pancreatitis DMXAA activates STING signaling and limits Th 17 response in the pancreas, significantly relieving CP symptoms C57BL/6J mice, C57BL/6J-Tmem 173gt/J mice DMXAA/STING activated [79] Pancreatic cancer Inhibition of DTX 3L leads to enhanced activation of cGAS-STING signaling pathway and improves anti-tumor immunity in pancreatic cancer C57BL/6J mice(F) DTX3L/STING activated [88] Colorectal Ulcerative colitis PAD4-mediated NETs activate the cGAS-STING pathway in a dose- and time-dependent manner, leading to the secretion of inflammatory cytokines and impaired barrier function C57BL/6 mice PAD4/NETs/STING activated [101] ANP repairs the intestinal barrier and inhibits ER stress-induced autophagy by inhibiting STING 8week-old C57BL/6 mice(M) ANP/STING inhibited [94] Copyright ©2026 The Author(s).
Expressing:Article Title: Targeting the cGAS-STING Pathway: An Emerging Therapeutic Strategy for Digestive Diseases.
Article Snippet: Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology Copyright ©2026 The Author(s). .. Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology Liver HBV interacting with STING and inhibiting ubiquitination at its K63 site HepaRG cells primary human hepatocytes HBV replication was significantly inhibited when the cGAS-STING pathway was activated by either dsDNA or cGAMP cancer patients, mice STING activated [40] NAFLD STING levels in non-solid cells of liver tissue were higher in NAFLD patients than in non-NAFLD patients. mice with disruption of Tmem173 STING activated [115] NASH STING deficiency attenuates hepatic steatosis, fibrosis and inflammation in two NASH mouse models NASH in mice STING inhibited [48] ALD Disruption of Cx32 impairs IRF3 gene expression ALD patient Cx32KO mice STING inhibited [51] IRI Knockdown of STING in macrophages significantly attenuates aging-related deterioration of hepatic IRIs C57/BL6 mice STING inhibited [54] Liver fibrosis XBP1 regulates macrophage mtDNA cytoplasmic leakage via BNIP3-mediated regulation of mitochondrial autophagy to activate macrophage cGAS/STING/NLRP3 and exacerbate liver fibrosis mice and patients with Xbp1 knockout XBP1/STING/NLRP3 activated [62] Fluoropropylene oxide trimeric acid (HFPO-TA) mediates cellular cGAS/STING/NLRP3 activation through mitochondrial ROS (mtROS) overexpression and accelerates liver fibrosis progression C57/BL6 mice STING/NLRP3 activated [63] Hepatocellular Carcinoma TET2-mediated IL-2/STAT5A signaling upregulates cGAS expression in hepatocellular carcinoma tumors and produces cGAMP. cGAMP is Hepa1-6 Huh7 TET2/IL-2/STAT5A/ STING activated [66] Copyright ©2026 The Author(s). .. Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology transported through LRRC8C channels to activate STING in endothelial cells Pancreatic Acute pancreatitis STING is activated by sensing PAC death and promotes inflammatory cytokine and IFN production, exacerbating AP severity C57BL/6J mice C57BL/6J-Tmem 173gt/J mice TMEM 173/STING activated [74] Knockdown of wip 1 inhibits the STING-TBK 1 signaling pathway, suppresses AP autophagy, and reduces AP severity 28-week-old male SD rats Wip1/STING inhibited [77] Inhibition of the pro-inflammatory factor enhancer JMJD3 blocked mtDNA oxidation and knocked down the TLR 9/STING pathway effectively reduced inflammation C57BL/6 mice(M) JMJD3/TLR9/STING inhibited [75] SSd protects PAC from rainfroggin-induced pyroptosis by attenuating mitochondrial damage and inhibiting the cGAS-STING signaling pathway, attenuating AP AR42J cell line SSd/STING inhibited [76] Chronic Pancreatitis DMXAA activates STING signaling and limits Th 17 response in the pancreas, significantly relieving CP symptoms C57BL/6J mice, C57BL/6J-Tmem 173gt/J mice DMXAA/STING activated [79] Pancreatic cancer Inhibition of DTX 3L leads to enhanced activation of cGAS-STING signaling pathway and improves anti-tumor immunity in pancreatic cancer C57BL/6J mice(F) DTX3L/STING activated [88] Colorectal Ulcerative colitis PAD4-mediated NETs activate the cGAS-STING pathway in a dose- and time-dependent manner, leading to the secretion of inflammatory cytokines and impaired barrier function C57BL/6 mice PAD4/NETs/STING activated [101] ANP repairs the intestinal barrier and inhibits ER stress-induced autophagy by inhibiting STING 8week-old C57BL/6 mice(M) ANP/STING inhibited [94] Copyright ©2026 The Author(s).
Infection:Article Title: Human adipose tissue as a reservoir for memory CD4+ T cells and HIV
Article Snippet: Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. .. Patient Gender, age Viral load (RNA copies/ml) CD4+ count (cells/μl) ART BMI 01 (Live) M, 39 <50 288 Yes 26 02 (Cadaver) M, 60 ND ND Yes ND 03 (Live) F, 36 <50 142 Yes 37 04 (Live) F, 50 <50 623 Yes 32 05 (Cadaver) M, 39 >500,000 53 No 16 HIV patient characteristics(a) Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. are major sources of IL6, and the combination of IL2 and proinflammatory cytokines induces HIV replication from latently infected CD4þ T cells [21,22]. ..
other:Article Title: Low-Level Viremia Is Associated With Clinical Progression in HIV-Infected Patients Receiving Antiretroviral Treatment
Article Snippet: JAIDS Journal of Acquired Immune Deficiency Syndromes Publish Ahead of Print DOI: 10.1097/QAI.0000000000001678
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